Pinky and Brain are genetically enhanced laboratory mice who reside in a cage in the Acme Labs research facility. Brain is self-centered and scheming; Pinky is good-natured but feebleminded. In each episode, Brain devises a new plan to take over the world, which ultimately ends in failure, usually due to Pinky's idiocy, the impossibility of Brain's plan, Brain's own arrogance, or just circumstances beyond their control.
Season 1
S01E01 Das Mouse
Brain hatches a plot to hypnotize people, but he needs white crab meat to succeed. In order to get the crab meat, he takes a submarine to the wreck of the Titanic. Unfortunately, the CIA spots his sub and orders its destruction.
S01E02 Of Mouse and Man
Brain plans to take over the world by creating a voice mail system that will tie up everyone on the planet long enough for him to take over. In order to do this he needs money. He decides to get it by getting a job and then staging an accident in order to sue the company.
S01E03 Tokyo Grows That Smarts Brainstem
Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up.
S01E04 Pinky & the Fog Where No Mouse Has Gone Before Cheese Roll Call
Brain makes Pinky smarter so his stupidity won't ruin anymore plans.
S01E05 Brainania
Pinky and Brain perform a song about the brain.
S01E06 TV or Not TV
Brain gains the ability to cloud the minds of men with his voice. He tries to get on the radio by adapting the persona of "The Fog". Unfortunately his plan falls apart when he gets to the studio.
S01E07 Napoleon Brainaparte
Brain hears that a space probe is about to be launched. On the probe is a plaque with a representation of man and woman. Brain changes the plaque to make it appear that he rules the world. Aliens discover the probe and take Pinky and the Brain to their planet where they honor them just like they are "honored" on Earth.
S01E08 A Pinky & the Brain Christmas
Pinky sings about cheese.
S01E09 Snowball
The Brain hatches a plan to take over the world by using static electricity to shock the world into submission. Unfortunately he needs several billion dollars to build a giant clothes dryer. Pinky and the Brain head to Island X where they set up a fake country and hope to get a giant foreign aid loan from the United States.
S01E10 Around the World in 80 Narfs
Brain develops a special pair of dentures that can produce a smile that can hypnotize anyone who is not wearing a special pair of sunglasses. In order to take over the world, he needs people to see the mesmerizing smile. He figures that he needs to get on TV and in order to do that he has to become a celebrity.
S01E11 Fly
While France awaits Napoleon's triumphant return from Austria, Brain develops a recipe for exploding crepe-suzettes in an effort to conquer France. He uses the recipe in a cooking class and when the crepes explode, he is arrested. When he is taken to prison, however, his luck begins to change when people mistake him for Napoleon Bonaparte.
S01E12 Ambulatory Abe Mouse of La Mancha
Pinky and the Brain head to the North Pole. Pinky just wants to see Santa, but the Brain has a more sinister plan. He wants pretend to be an elf so that he can mass produce a hypnotic doll named "Noddle Noggin" in Santa's workshop. He then hopes that Santa will distribute the toy all over world so he can take over.
S01E13 The Third Mouse the Visit
Brain comes face to face with his former friend and now enemy, Snowball. And it seems Snowball has his own plans to take over the world.
Season 2
S02E01 It's Only a Paper World
Brain tries to get all the people off Earth onto his paper mache creation, Chia Earth.
S02E02 Collect 'Em All Pinkasso
Using Johannes Gutenberg printing press, the Brain make a series of collectible trading cards.
S02E03 Plan Brain From Outer Space
A successful modern artist is born and it's Pinky, trying to help fund Brain's new plan.
S02E04 The Pink Candidate
Brain hopes his inter-galactic pen pal, Zalgar, will help him take over the world. But it turns out Zalgar likes to snack on brains.
S02E05 Brain's Song
Pinky writes a letter to the newspaper criticizing the comic strip "The Family Circus". His letter, however, is misunderstood as a political statement that thrusts him to a spotlight that leads him to the Presidency of the United States. Pinky's administration, however, must deal with a scandal when the Brain's plans to take over the world are made public.
S02E06 Welcome to the Jungle
Brain makes a tearjerker movie to make the world sad enough to make him leader.
S02E07 A Little Off the Top Megalomaniacs Anonymous
Animal rights activist think Pinky and the Brain are monkeys and release them into the jungle after taking them out of Acme Labs. The pair try to make it back home, but run into the Brain's old enemy Snowball.
S02E08 The Mummy Robin Brain
Brain tries to discover what makes the legendary Samson so strong.
S02E09 Two Mice and a Baby the Maze
When Brain comes to the conclusion he no longer wants to take over the world, he decides to help others who had his problem and the first one to be helped is Pinky.
S02E10 Brain of the Future
Pinky and Brain get sealed in an Egyptian pyramid where a mummy is lurking about.
S02E11 Brinky
Brain gets a group of men to steal money from the rich (ala Robin Hood) to pay for his new plot.
S02E12 Hoop Schemes
Pinky and Brain stumble upon a super powered baby, who happened to arrive from an exploding alien world.
Season 3
S03E01 Leave It to Beavers Cinebrainia
Brain enlists the aid of beavers to gain control over the flow of rivers.
S03E02 Brain Noir
The mice make a series of comedy films and hit the big time.
S03E03 Pinky & the Brain And Larry Where the Deer and the Mouselopes Play
Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out.
S03E04 Brain Bogie Say What, Earth
In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.
S03E05 My Feldmans, My Friends
It's 1946 and Brain's new plan gets interrupted when he and Pinky encounter Billie and Snowball.
S03E06 All You Need Is Narf Pinky's Plan
Brain gets caught up in winning a golf tournament, even though it interferes with his new plan.
S03E07 This Old Mouse
After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.
S03E08 Brain Storm
Brain tries to get a package meant for him back from his neighbor.
S03E09 A Meticulous Analysis of History Funny, You Don't Look Rhennish
Pinky becomes a guru during the 1960s.
S03E10 The Pinky Protocol
It's Brain's birthday and Pinky plans a surprise party.
S03E11 Mice Don't Dance Brain Drained
After getting a glimpse of his future, Brain abandons his attempts to take over the world and gets a job as a ski instructor.
S03E12 Brain Acres
The mice are looking to control tornados, but a pest keeps getting in their way.
S03E13 Pinky and the Brainmaker Calvin Brain
Brain sings about past and present world leaders' failures.
S03E14 Pinky Suavo T H E Y
The mice need to get into a mine, but have to pretend to join a Amish-type society.
S03E15 The Real Life
Brain's latest plan is a conspiracy theory about why he is not ruling the world.
S03E16 Brain's Way
Brain becomes a tap dancer with steam-powered legs in order to spread a subliminal morse code at the World's Fair.
S03E17 A Pinky and the Brain Halloween
Brain is out of ideas for taking over the world, so he tries to get some from writers.
S03E18 Brainy Jack
Farmer Brain tries to grow an army of monster vegetables.
S03E19 Leggo My Ego Big in Japan
Brain creates a cloning machine and plans to clone himself in order to create the best Celtic dance troupe the world has ever seen.
S03E20 But, That's Not All Folks
Brain masquerades as a fashion designer.
S03E21 Operation Sea Lion You Said a Mouseful
Brain plans to use the Personalitron to give him irresistible charisma, but it winds up going to Pinky.
S03E22 The Tailor and the Mice Bah, Wilderness
The mice learn of a secret organization, T.H.E.Y. (comprised of world leaders), and try to get in.
S03E23 Pinky at the Bat Schpiel-Borg 2000
A house needed for Brain's latest plot becomes the set of a reality series about the people living there. So the mice become participants to get in.
S03E24 Broadway Malady
To save his Las Vegas casino, Brain works as a lounge singer.
S03E25 Brainie the Pooh Melancholy Brain
Mr. Itch offers Brain control of the world in exchange for his soul, but Brain refuses. In a shocking twist, Pinky sells his soul to make it happen and Brain soon decides to get his friend back.
S03E26 Inherit the Wheeze
Brain assumes the identity of Briany Jack, a hippie leader, and tries to create a peace chain to send a subliminal message.
S03E27 Brain's Night Off Beach Blanket Brain
Brain's attempt to control Emperor Franz Josef get side tracked when he talks about his problems with psychiatrist Dr. Sigmund Freud.
S03E28 The Family That Poits Together, Narfs Together
Brain enters the world of a sumo wrestling to acquire a paralyzing fish.
S03E29 Pinky's Turn Your Friend, Global Domination
Brain takes control of a satellite to air his infomercial around the world, but the satellite belongs to the military and they want to capture whoever hacked into their systems.
S03E30 You'll Never Eat Food Pellets in This Town Again!
Brain takes control over aquatic mammals for his latest plan and Pinky falls for a female sea lion.
S03E31 Dangerous Brains
Brain tries to change the Earth's weather patterns.
S03E32 Whatever Happened to Baby Brain Just Say Narf
A well-meaning tailor makes Pinky and Brain's lives miserable.
S03E33 Pinky's P O V the Really Great Dictator Brain Food
At a sleep away camp for world leaders' children, Brain tries to trick the children into placing listening devices in their parents' offices.
Season 4
S04E01 Brainwashed Pt 1 Brain, Brain Go Away
Pinky and Brain are kidnapped in Washington, DC by an unknown force. Brain loses his memory and the mice are then imprisoned in a town where everyone is forced to perform the Schëerskåhøvên, which is dumbing down the entire country.
S04E02 Brainwashed Pt 2 I Am Not a Hat!
Brain regains his memory and the mice escape. They believe Snowball is responsible for the Schmëerskåhøvên, but him imprisoned in a mental institution.
S04E03 Brainwashed Pt 3 Wash Harder
The mice and Snowball search for the one who spliced their DNA, Dr. Mordough, thinking he's responsible for all this. But it turns out to be his cat, Precious, and time is running out.
S04E04 To Russia With Lab Mice Hickory Dickory Bonk
Pinky and Brain's plan to alter caviar with a mutating capsule is complicated by a Russian lab mouse.
S04E05 The Pinky and the Brain Reunion Special
Brain plots to make every clock on Earth chime repeatedly.
S04E06 A Legendary Tail Project Brain
A special of highlights of their career is on the air, but it's really all a ruse so Pinky and Brain can hypnotize the viewers.
S04E07 Star Warners
Inspired by legends of the past, Brain tries to create a legend about himself to gain world acclaim.